1du3
From Proteopedia
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Crystal structure of TRAIL-SDR5
Contents |
Overview
TRAIL is a cytokine that induces apoptosis in a wide variety of tumor, cells but rarely in normal cells. It contains an extraordinarily elongated, loop because of an unique insertion of 12-16 amino acids compared with the, other members of tumor necrosis factor family. Biological implication of, the frame insertion has not been clarified. We have determined the crystal, structure of TRAIL in a complex with the extracellular domain of death, receptor DR5 at 2.2 A resolution. The structure reveals extensive contacts, between the elongated loop and DR5 in an interaction mode that would not, be allowed without the frame insertion. These interactions are missing in, the structures of the complex determined by others recently. This, observation, along with structure-inspired deletion analysis, identifies, the critical role of the frame insertion as a molecular strategy, conferring specificity upon the recognition of cognate receptors. The, structure also suggests that a built-in flexibility of the tumor necrosis, factor receptor family members is likely to play a general and important, role in the binding and recognition of tumor necrosis factor family, members.
Disease
Known diseases associated with this structure: Squamous cell carcinoma, head and neck OMIM:[603612]
About this Structure
1DU3 is a Protein complex structure of sequences from Homo sapiens with ZN as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of TRAIL-DR5 complex identifies a critical role of the unique frame insertion in conferring recognition specificity., Cha SS, Sung BJ, Kim YA, Song YL, Kim HJ, Kim S, Lee MS, Oh BH, J Biol Chem. 2000 Oct 6;275(40):31171-7. PMID:10893238
Page seeded by OCA on Mon Nov 12 16:35:58 2007
Categories: Homo sapiens | Protein complex | Cha, S.S. | Oh, B.H. | Sung, B.J. | ZN | Complex | Dr5 | Trail
