1dvp
From Proteopedia
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CRYSTAL STRUCTURE OF THE VHS AND FYVE TANDEM DOMAINS OF HRS, A PROTEIN INVOLVED IN MEMBRANE TRAFFICKING AND SIGNAL TRANSDUCTION
Overview
We have determined the 2 A X-ray structure of the 219-residue N-terminal, VHS and FYVE tandem domain unit of Drosophila Hrs. The unit assumes a, pyramidal structure in which the much larger VHS domain (residues 1-153), forms a rectangular base and the FYVE domain occupies the apical end. The, VHS domain is comprised of an unusual "superhelix" of eight alpha helices, and the FYVE domain is mainly built of loops, two double-stranded, antiparallel sheets, and a helix stabilized by two tetrahedrally, coordinated zinc atoms. The two-domain structure forms an exact, 2-fold-related homodimer through antiparallel association of mainly FYVE, domains. Dimerization creates two identical pockets designed for binding, ligands with multiple negative charges such as citrate or, phosphatidylinositol 3-phosphate.
About this Structure
1DVP is a Single protein structure of sequence from Drosophila melanogaster with ZN and CIT as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction., Mao Y, Nickitenko A, Duan X, Lloyd TE, Wu MN, Bellen H, Quiocho FA, Cell. 2000 Feb 18;100(4):447-56. PMID:10693761
Page seeded by OCA on Tue Nov 20 13:37:34 2007
Categories: Drosophila melanogaster | Single protein | Bellen, H. | Duan, X. | Lloyd, T.E. | Mao, Y. | Nickitenko, A. | Quiocho, F.A. | Wu, M.N. | CIT | ZN | Fyve | Hrs | Superhelix | Vhs | Zinc finger
