2e9w

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Template:STRUCTURE 2e9w

Contents 1 Crystal structure of the extracellular domain of Kit in complex with stem cell factor (SCF) 2 Disease 3 About this Structure 4 Reference

Crystal structure of the extracellular domain of Kit in complex with stem cell factor (SCF)

Template:ABSTRACT PUBMED 17662946

Disease

Known disease associated with this structure: Gastrointestinal stromal tumor, somatic OMIM:[164920], Germ cell tumors OMIM:[164920], Leukemia, acute myeloid OMIM:[164920], Mast cell leukemia OMIM:[164920], Mastocytosis with associated hematologic disorder OMIM:[164920], Piebaldism OMIM:[164920], Skin/hair/eye pigmentation 7, blond/brown hair OMIM:[184745]

About this Structure

2E9W is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Yuzawa S, Opatowsky Y, Zhang Z, Mandiyan V, Lax I, Schlessinger J. Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor. Cell. 2007 Jul 27;130(2):323-34. PMID:17662946 doi:http://dx.doi.org/10.1016/j.cell.2007.05.055

Page seeded by OCA on Tue Feb 17 08:32:18 2009