1dxz
From Proteopedia
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M2 TRANSMEMBRANE SEGMENT OF ALPHA-SUBUNIT OF NICOTINIC ACETYLCHOLINE RECEPTOR FROM TORPEDO CALIFORNICA, NMR, 20 STRUCTURES
Overview
A synthetic peptide corresponding to the transmembrane segment M2, (residues 236-267) of the alpha-subunit of the nicotinic acetylcholine, receptor from Torpedo californica has been studied by two dimensional, 1H-NMR spectroscopy in a chloroform-methanol (1:1) mixture containing 0.1, M LiClO4. Reconstruction of the spatial structure of M2 from the NMR data, resulted in an alpha-helix formed by residues 241-263. Distribution of the, molecular hydrophobicity potential on the helix surface is very similar to, that in five-helix bundles of proteins with a known three dimensional, structure: two hydrophilic bands located on the opposite helix sides, separated by strong hydrophobic zones.
About this Structure
1DXZ is a Single protein structure of sequence from Torpedo californica with NH2 as ligand. Full crystallographic information is available from OCA.
Reference
Spatial structure of the M2 transmembrane segment of the nicotinic acetylcholine receptor alpha-subunit., Pashkov VS, Maslennikov IV, Tchikin LD, Efremov RG, Ivanov VT, Arseniev AS, FEBS Lett. 1999 Aug 20;457(1):117-21. PMID:10486576
Page seeded by OCA on Tue Nov 20 13:40:04 2007
