2pr3

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Image:2pr3.png

Template:STRUCTURE 2pr3

Contents

Factor XA inhibitor

Template:ABSTRACT PUBMED 17581239

Disease

Known disease associated with this structure: Factor X deficiency OMIM:[227600]

About this Structure

2PR3 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Van Huis CA, Bigge CF, Casimiro-Garcia A, Cody WL, Dudley DA, Filipski KJ, Heemstra RJ, Kohrt JT, Narasimhan LS, Schaum RP, Zhang E, Bryant JW, Haarer S, Janiczek N, Leadley RJ Jr, McClanahan T, Thomas Peterson J, Welch KM, Edmunds JJ. Structure-based drug design of pyrrolidine-1, 2-dicarboxamides as a novel series of orally bioavailable factor Xa inhibitors. Chem Biol Drug Des. 2007 Jun;69(6):444-50. PMID:17581239 doi:10.1111/j.1747-0285.2007.00520.x

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