1eik
From Proteopedia
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SOLUTION STRUCTURE OF RNA POLYMERASE SUBUNIT RPB5 FROM METHANOBACTERIUM THERMOAUTOTROPHICUM
Overview
RPB5 is an essential subunit of eukaryotic and archaeal RNA polymerases., It is a proposed target for transcription activator proteins in, eukaryotes, but the mechanism of interaction is not known. We have, determined the solution structure of the RPB5 subunit from the, thermophilic archeon, Methanobacterium thermoautotrophicum. MtRBP5, contains a four-stranded beta-sheet platform supporting two alpha-helices, one on each side of the beta-sheet, resulting in an overall mushroom shape, that does not appear to have any structural homologues in the structural, database. The position and conservation of charged surface residues, suggests possible modes of interaction with other proteins, as well as a, rationale for the thermal stability of this protein.
About this Structure
1EIK is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Active as DNA-directed RNA polymerase, with EC number 2.7.7.6 Full crystallographic information is available from OCA.
Reference
Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum., Yee A, Booth V, Dharamsi A, Engel A, Edwards AM, Arrowsmith CH, Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6311-5. PMID:10841538
Page seeded by OCA on Tue Nov 20 14:01:40 2007
Categories: DNA-directed RNA polymerase | Methanothermobacter thermautotrophicus | Single protein | Arrowsmith, C.H. | Booth, V. | Dharamsi, A. | Edwards, A.M. | Engel, A. | NESG, Northeast.Structural.Genomics.Consortium. | Yee, A. | Nesg | Northeast structural genomics consortium | Ocsp | Protein structure initiative | Psi | Rna polymerase subunit | Rpb5 | Rpbh | Structural genomics
