1el3
From Proteopedia
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HUMAN ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR
Overview
The crystallographic structure of the complex between human aldose, reductase (AR2) and one of its inhibitors, IDD384, has been solved at 1.7, A resolution from crystals obtained at pH 5.0. This structure shows that, the binding of the inhibitor's hydrophilic head to the catalytic residues, Tyr48 and His110 differs from that found previously with porcine AR2. The, difference is attributed to a change in the protonation state of the, inhibitor (pK(a) = 4.52) when soaked with crystals of human (at pH 5.0) or, pig lens AR2 (at pH 6.2). This work demonstrates how strongly the detailed, binding of the inhibitor's polar head depends on its protonation state.
About this Structure
1EL3 is a Single protein structure of sequence from Homo sapiens with NAP and I84 as ligands. Active as Aldehyde reductase, with EC number 1.1.1.21 Full crystallographic information is available from OCA.
Reference
The structure of human aldose reductase bound to the inhibitor IDD384., Calderone V, Chevrier B, Van Zandt M, Lamour V, Howard E, Poterszman A, Barth P, Mitschler A, Lu J, Dvornik DM, Klebe G, Kraemer O, Moorman AR, Moras D, Podjarny A, Acta Crystallogr D Biol Crystallogr. 2000 May;56(Pt 5):536-40. PMID:10771421
Page seeded by OCA on Mon Nov 12 16:44:33 2007
