2ohs

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Image:2ohs.png

Template:STRUCTURE 2ohs

X-ray crystal structure of beta secretase complexed with compound 6b

Template:ABSTRACT PUBMED 17315857

About this Structure

2OHS is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Congreve M, Aharony D, Albert J, Callaghan O, Campbell J, Carr RA, Chessari G, Cowan S, Edwards PD, Frederickson M, McMenamin R, Murray CW, Patel S, Wallis N. Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase. J Med Chem. 2007 Mar 22;50(6):1124-32. Epub 2007 Feb 22. PMID:17315857 doi:10.1021/jm061197u

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