2irz

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Image:2irz.png

Template:STRUCTURE 2irz

Crystal structure of human Beta-secretase complexed with inhibitor

Template:ABSTRACT PUBMED 17149856

About this Structure

2IRZ is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Rajapakse HA, Nantermet PG, Selnick HG, Munshi S, McGaughey GB, Lindsley SR, Young MB, Lai MT, Espeseth AS, Shi XP, Colussi D, Pietrak B, Crouthamel MC, Tugusheva K, Huang Q, Xu M, Simon AJ, Kuo L, Hazuda DJ, Graham S, Vacca JP. Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1). J Med Chem. 2006 Dec 14;49(25):7270-3. PMID:17149856 doi:10.1021/jm061046r

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