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3edz
From Proteopedia
Crystal structure of catalytic domain of TACE with hydroxamate inhibitor
Template:ABSTRACT PUBMED 18835710
About this Structure
3EDZ is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Mazzola RD Jr, Zhu Z, Sinning L, McKittrick B, Lavey B, Spitler J, Kozlowski J, Neng-Yang S, Zhou G, Guo Z, Orth P, Madison V, Sun J, Lundell D, Niu X. Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5809-14. Epub 2008 Sep 13. PMID:18835710 doi:10.1016/j.bmcl.2008.09.045
Page seeded by OCA on Wed Jun 3 08:43:15 2009
Categories: ADAM 17 endopeptidase | Homo sapiens | Guo, Z. | Kozlowski, J. | Lavey, B. | Lundell, D. | Madison, V. | Mazzola, R D. | McKittrick, B. | Neng-Yang, S. | Niu, X. | Orth, P. | Sinning, L. | Spitler, J. | Sun, J. | Zhou, G. | Zhu, Z. | Alternative splicing | Cleavage on pair of basic residue | Glycoprotein | Hydrolase | Membrane | Metal-binding | Metalloprotease | Notch signaling pathway | Phosphoprotein | Protease | Sh3-binding | Transmembrane | Zinc | Zn-endopeptidase | Zymogen
