1z3n

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Template:STRUCTURE 1z3n

Contents 1 Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom 2 About this Structure 3 See Also 4 Reference

Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom

Template:ABSTRACT PUBMED 15857120

About this Structure

1z3n is a 1 chain structure of Aldose Reductase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Aldose Reductase

Reference

• Van Zandt MC, Jones ML, Gunn DE, Geraci LS, Jones JH, Sawicki DR, Sredy J, Jacot JL, Dicioccio AT, Petrova T, Mitschler A, Podjarny AD. Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. J Med Chem. 2005 May 5;48(9):3141-52. PMID:15857120 doi:10.1021/jm0492094