2puq

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Template:STRUCTURE 2puq

Contents 1 Crystal structure of active site inhibited coagulation factor VIIA in complex with soluble tissue factor 2 Disease 3 About this Structure 4 Reference

Crystal structure of active site inhibited coagulation factor VIIA in complex with soluble tissue factor

Template:ABSTRACT PUBMED 17456045

Disease

Known disease associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500], Renal tubular dysgenesis OMIM:[106180], Angiotensin I-converting enzyme, benign serum increase OMIM:[106180], Alzheimer disease, susceptibility to OMIM:[106180], Microvascular complications of diabetes 3 OMIM:[106180], Myocardial infarction, susceptibility to OMIM:[106180], SARS, progression of OMIM:[106180]

About this Structure

2PUQ is a 4 chains structure of sequences from Homo sapiens. This structure supersedes the now removed PDB entry 2pmm. Full crystallographic information is available from OCA.

Reference

• Larsen KS, Ostergaard H, Bjelke JR, Olsen OH, Rasmussen HB, Christensen L, Kragelund BB, Stennicke HR. Engineering the substrate and inhibitor specificities of human coagulation Factor VIIa. Biochem J. 2007 Aug 1;405(3):429-38. PMID:17456045 doi:http://dx.doi.org/10.1042/BJ20061901

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