2fbv

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spinqualitylabelsall models PDB ID 2fbv Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2fbv, resolution 2.40Å ()
Ligands:
Gene:	WRN, RECQ3, RECQL2 (Homo sapiens)
Related:	2fbt, 2fbx, 2fby, 2fc0
Structural annotation: Resources: InterPro : Ipr004589, Ipr014021, Ipr014001, Ipr002464, Ipr001650, Ipr002121, Ipr002562, Ipr012337, Ipr011545 Pfam : PF01612 UniProt : Q14191
Functional annotation: Cellular component: nucleus intracellular Biological process: regulation of growth rate aging DNA recombination telomere maintenance Molecular function: 3'-5' exonuclease activity hydrolase activity DNA binding helicase activity nucleotide binding ATP binding DNA helicase activity nucleic acid binding protein binding ATP-dependent helicase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

WRN exonuclease, Mn complex

Template:ABSTRACT PUBMED 16622405

About this Structure

2FBV is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Perry JJ, Yannone SM, Holden LG, Hitomi C, Asaithamby A, Han S, Cooper PK, Chen DJ, Tainer JA. WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat Struct Mol Biol. 2006 May;13(5):414-22. Epub 2006 Apr 23. PMID:16622405 doi:http://dx.doi.org/10.1038/nsmb1088

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