1tp0

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Image:1tp0.png

Template:STRUCTURE 1tp0

Contents

Triple mutation in interleukin 1 beta cavity:replacement of phenylalanines with tryptophan.

Template:ABSTRACT PUBMED 15663946

Disease

Known disease associated with this structure: Gastric cancer risk after H. pylori infection OMIM:[147720]

About this Structure

1TP0 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Adamek DH, Guerrero L, Blaber M, Caspar DL. Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J Mol Biol. 2005 Feb 11;346(1):307-18. Epub 2004 Dec 24. PMID:15663946 doi:10.1016/j.jmb.2004.11.046

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