1twx

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Image:1twx.png

Template:STRUCTURE 1twx

Contents

Crystal structure of the thrombin mutant D221A/D222K

Template:ABSTRACT PUBMED 15572256

Disease

Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

1TWX is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Pineda AO, Zhang E, Guinto ER, Savvides SN, Tulinsky A, Di Cera E. Crystal structure of the thrombin mutant D221A/D222K: the Asp222:Arg187 ion-pair stabilizes the fast form. Biophys Chem. 2004 Dec 20;112(2-3):253-6. PMID:15572256 doi:http://dx.doi.org/10.1016/j.bpc.2004.07.027

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