1gd5

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SOLUTION STRUCTURE OF THE PX DOMAIN FROM HUMAN P47PHOX NADPH OXIDASE

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The phox homology (PX) domain is a novel protein module containing a, conserved proline-rich motif. We have shown that the PX domain isolated, from the human p47phox protein, a soluble subunit of phagocyte NADPH, oxidase, binds specifically to the C-terminal SH3 domain derived from the, same protein. The solution structure of p47 PX has an alpha + beta, structure with a novel folding motif topology and reveals that the, proline-rich motif is presented on the molecular surface for easy, recognition by the SH3 domain. The proline-rich motif of p47 PX in the, free state adopts a distorted left-handed polyproline type II helix, conformation.

Disease

Known disease associated with this structure: Chronic granulomatous disease due to deficiency of NCF-1 OMIM:[608512]

About this Structure

1GD5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the PX domain, a target of the SH3 domain., Hiroaki H, Ago T, Ito T, Sumimoto H, Kohda D, Nat Struct Biol. 2001 Jun;8(6):526-30. PMID:11373621

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