1ta2

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Template:STRUCTURE 1ta2

Contents

Crystal structure of thrombin in complex with compound 1

Template:ABSTRACT PUBMED 9703466

About this Structure

1ta2 is a 2 chain structure of Hirudin with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Tucker TJ, Brady SF, Lumma WC, Lewis SD, Gardell SJ, Naylor-Olsen AM, Yan Y, Sisko JT, Stauffer KJ, Lucas BJ, Lynch JJ, Cook JJ, Stranieri MT, Holahan MA, Lyle EA, Baskin EP, Chen IW, Dancheck KB, Krueger JA, Cooper CM, Vacca JP. Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position. J Med Chem. 1998 Aug 13;41(17):3210-9. PMID:9703466 doi:http://dx.doi.org/10.1021/jm9801713

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