3br9

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Template:STRUCTURE 3br9

Contents 1 Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor 2 About this Structure 3 See Also 4 Reference

Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor

Template:ABSTRACT PUBMED 18242088

About this Structure

3br9 is a 2 chain structure of RNA polymerase with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

See Also

• RNA polymerase

Reference

• Zhou Y, Webber SE, Murphy DE, Li LS, Dragovich PS, Tran CV, Sun Z, Ruebsam F, Shah AM, Tsan M, Showalter RE, Patel R, Li B, Zhao Q, Han Q, Hermann T, Kissinger CR, Lebrun L, Sergeeva MV, Kirkovsky L. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5- hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1413-8. Epub 2008 Jan 8. PMID:18242088 doi:S0960-894X(08)00010-3