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1gp0
From Proteopedia
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HUMAN IGF2R DOMAIN 11
Contents |
Overview
Insulin-like growth factor II receptor (IGF2R) is a multifunctional cell, surface receptor implicated in tumour suppression. Its growth inhibitory, activity has been associated with an ability to bind IGF-II. IGF2R, contains 15 homologous extracellular domains, with domain 11 primarily, responsible for IGF-II binding. We report a 1.4 A resolution crystal, structure of domain 11, solved using the anomalous scattering signal of, sulfur. The structure consists of two crossed beta-sheets forming a, flattened beta-barrel. Structural analysis identifies the putative IGF-II, binding site at one end of the beta-barrel whilst crystal lattice contacts, suggest a model for the full-length IGF2R extracellular region. The, structure factors and coordinates of IGF2R domain 11 have been deposited, in the Protein Data Bank (accession codes 1GP0 and 1GP3).
Disease
Known diseases associated with this structure: Hepatocellular carcinoma OMIM:[147280]
About this Structure
1GP0 is a Single protein structure of sequence from Homo sapiens with SO4 as ligand. Full crystallographic information is available from OCA.
Reference
Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur., Brown J, Esnouf RM, Jones MA, Linnell J, Harlos K, Hassan AB, Jones EY, EMBO J. 2002 Mar 1;21(5):1054-62. PMID:11867533
Page seeded by OCA on Mon Nov 12 17:07:40 2007
