2ftd

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Image:2ftd.png

Template:STRUCTURE 2ftd

Crystal structure of Cathepsin K complexed with 7-Methyl-Substituted Azepan-3-one compound

Template:ABSTRACT PUBMED 16509577

About this Structure

2FTD is a 2 chains structure of sequences from Macaca mulatta. Full crystallographic information is available from OCA.

Reference

  • Yamashita DS, Marquis RW, Xie R, Nidamarthy SD, Oh HJ, Jeong JU, Erhard KF, Ward KW, Roethke TJ, Smith BR, Cheng HY, Geng X, Lin F, Offen PH, Wang B, Nevins N, Head MS, Haltiwanger RC, Narducci Sarjeant AA, Liable-Sands LM, Zhao B, Smith WW, Janson CA, Gao E, Tomaszek T, McQueney M, James IE, Gress CJ, Zembryki DL, Lark MW, Veber DF. Structure activity relationships of 5-, 6-, and 7-methyl-substituted azepan-3-one cathepsin K inhibitors. J Med Chem. 2006 Mar 9;49(5):1597-612. PMID:16509577 doi:10.1021/jm050915u

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