3hhr

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Image:3hhr.png

Template:STRUCTURE 3hhr

Contents

HUMAN GROWTH HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR: CRYSTAL STRUCTURE OF THE COMPLEX

Template:ABSTRACT PUBMED 1549776

About this Structure

3hhr is a 3 chain structure of Hormone with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2hhr. The April 2004 RCSB PDB Molecule of the Month feature on Growth Hormone by Shuchismita Dutta and David S. Goodsell is 10.2210/rcsb_pdb/mom_2004_4. Full crystallographic information is available from OCA.

See Also

Reference

  • de Vos AM, Ultsch M, Kossiakoff AA. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science. 1992 Jan 17;255(5042):306-12. PMID:1549776
  • Gomez-Orellana I, Variano B, Miura-Fraboni J, Milstein S, Paton DR. Thermodynamic characterization of an intermediate state of human growth hormone. Protein Sci. 1998 Jun;7(6):1352-8. PMID:9655339 doi:10.1002/pro.5560070611
  • Duda KM, Brooks CL. Identification of residues outside the two binding sites that are critical for activation of the lactogenic activity of human growth hormone. J Biol Chem. 2003 Jun 20;278(25):22734-9. Epub 2003 Apr 7. PMID:12682073 doi:10.1074/jbc.M212550200
  • Kurihara Y, Watanabe T, Nojima H, Takeda-Shitaka M, Sumikawa H, Kamiya K, Umeyama H. Dynamic character of human growth hormone and its receptor: normal mode analysis. Chem Pharm Bull (Tokyo). 2003 Jul;51(7):754-8. PMID:12843579

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