1h6k

From Proteopedia

Revision as of 15:07, 12 November 2007 by OCA (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
Image:1h6k.gif

1h6k, resolution 2.00Å

Drag the structure with the mouse to rotate

NUCLEAR CAP BINDING COMPLEX

Overview

The heterodimeric nuclear cap binding complex (CBC) binds to 5'-capped, polymerase II transcripts. It enhances the efficiency of several mRNA, maturation steps and is essential for U snRNA nuclear export in, multicellular eukaryotes. The 2A crystal structure of human CBC shows that, the large subunit, CBP80, comprises three domains, each containing, consecutive helical hairpins and resembling the so-called MIF4G domain, found in several other proteins involved in RNA metabolism. The small, subunit, CPB20, has an RNP fold and associates with the second and third, domains of CBP80. Site-directed mutagenesis revealed 4 residues of CBP20, which are critical for cap binding. A model for cap binding is proposed, based on these results and the known mode of binding of RNA to RNP, domains.

About this Structure

1H6K is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human nuclear cap binding complex., Mazza C, Ohno M, Segref A, Mattaj IW, Cusack S, Mol Cell. 2001 Aug;8(2):383-96. PMID:11545740

Page seeded by OCA on Mon Nov 12 17:13:26 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1h6k"
Personal tools