3tza

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Image:3tza.png

Template:STRUCTURE 3tza

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 1.9A resolution

Template:ABSTRACT PUBMED 21923187

About this Structure

3tza is a 2 chain structure with sequence from Rattus norvegicus, synthetic, rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Szymanska E, Frydenvang K, Contreras-Sanz A, Pickering DS, Frola E, Serafimoska Z, Nielsen B, Kastrup JS, Johansen TN. A New Phenylalanine Derivative Acts as an Antagonist at the AMPA Receptor GluA2 and Introduces Partial Domain Closure: Synthesis, Resolution, Pharmacology, and Crystal Structure. J Med Chem. 2011 Oct 27;54(20):7289-98. Epub 2011 Oct 4. PMID:21923187 doi:10.1021/jm200862h

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