1hmy

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Image:1hmy.jpg

1hmy, resolution 2.5Å

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CRYSTAL STRUCTURE OF THE HHAL DNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYL-L-METHIONINE

Overview

The first three-dimensional structure of a DNA methyltransferase is, presented. The crystal structure of the DNA, (cytosine-5)-methyltransferase, M.HhaI (recognition sequence: GCGC), complexed with S-adenosyl-L-methionine has been determined and refined at, 2.5 A resolution. The core of the structure is dominated by sequence, motifs conserved among all DNA (cytosine-5)-methyltransferases, and these, are responsible for cofactor binding and methyltransferase function.

About this Structure

1HMY is a Single protein structure of sequence from Haemophilus haemolyticus with SAM as ligand. Active as DNA (cytosine-5-)-methyltransferase, with EC number 2.1.1.37 Full crystallographic information is available from OCA.

Reference

Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine., Cheng X, Kumar S, Posfai J, Pflugrath JW, Roberts RJ, Cell. 1993 Jul 30;74(2):299-307. PMID:8343957

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