1hq8
From Proteopedia
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CRYSTAL STRUCTURE OF THE MURINE NK CELL-ACTIVATING RECEPTOR NKG2D AT 1.95 A
Overview
NKG2D, a homodimeric lectin-like receptor, is a unique stimulatory, molecule that is found on natural killer cells,T cells and activated, macrophages.The natural ligands for murine NKG2D are distant major, histocompatibility complex homologs, retinoic acid early transcript (Rae1), and H-60 minor histocompatibility antigen. The crystal structure of the, extracellular region of murine NKG2D reveals close homology with other, C-type lectin receptors such as CD94, Ly49A, rat MBP-A and CD69. However, the precise mode of dimeric assembly varies among these natural killer, receptors, as well as their surface topography and electrostatic, properties.The NKG2D structure provides the first structural insights into, the role and ligand specificity of this stimulatory receptor in the innate, and adaptive immune system.
About this Structure
1HQ8 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A., Wolan DW, Teyton L, Rudolph MG, Villmow B, Bauer S, Busch DH, Wilson IA, Nat Immunol. 2001 Mar;2(3):248-54. PMID:11224525
Page seeded by OCA on Tue Nov 20 16:44:23 2007
