1hqr
From Proteopedia
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CRYSTAL STRUCTURE OF A SUPERANTIGEN BOUND TO THE HIGH-AFFINITY, ZINC-DEPENDENT SITE ON MHC CLASS II
Contents |
Overview
MHC class II molecules possess two binding sites for bacterial, superantigens (SAGs): a low-affinity site on the alpha chain and a, high-affinity, zinc-dependent site on the beta chain. Only the former has, been defined crystallographically. We report the structure of, streptococcal pyrogenic exotoxin C (SPE-C) complexed with HLA-DR2a, (DRA*0101, DRB5*0101) bearing a self-peptide from myelin basic protein, (MBP). SPE-C binds the beta chain through a zinc bridge that links the SAG, and class II molecules. Surprisingly, SPE-C also makes extensive contacts, with the MBP peptide, such that peptide accounts for one third of the, surface area of the MHC molecule buried in the complex, similar to, TCR-peptide/MHC complexes. Thus, SPE-C may optimize T cell responses by, mimicking the peptide dependence of conventional antigen presentation and, recognition.
Disease
Known diseases associated with this structure: Chronic infections, due to MBL deficiency OMIM:[154545], Diabetes mellitus, gestational, susceptibility to OMIM:[154545], Mannose-binding protein deficiency OMIM:[154545], Meningococcal disease, susceptibility to OMIM:[154545]
About this Structure
1HQR is a Protein complex structure of sequences from Homo sapiens and Streptococcus pyogenes with ZN as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II., Li Y, Li H, Dimasi N, McCormick JK, Martin R, Schuck P, Schlievert PM, Mariuzza RA, Immunity. 2001 Jan;14(1):93-104. PMID:11163233
Page seeded by OCA on Mon Nov 12 17:21:17 2007
