1hsk
From Proteopedia
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CRYSTAL STRUCTURE OF S. AUREUS MURB
Overview
The X-ray crystal structure of the substrate free form of Staphylococcus, aureus UDP-N-acetylenolpyruvylglucosamine reductase (MurB) has been solved, to 2.3 A resolution with an R-factor of 20.3% and a free R-factor of, 22.3%. While the overall fold of the S. aureus enzyme is similar to that, of the homologous Escherichia coli MurB X-ray crystal structure, notable, distinctions between the S. aureus and E. coli MurB protein structures, occur in residues involved in substrate binding. Analysis of available, MurB sequences from other bacteria suggest that the S. aureus MurB, structure is representative of a distinct structural class of, UDP-N-acetylenolpyruvylglucosamine reductases including Bacillus subtilis, and Helicobacter pylori that are characterized by a modified mechanism for, substrate binding.
About this Structure
1HSK is a Single protein structure of sequence from Staphylococcus aureus with FAD as ligand. Active as UDP-N-acetylmuramate dehydrogenase, with EC number 1.1.1.158 Full crystallographic information is available from OCA.
Reference
A structural variation for MurB: X-ray crystal structure of Staphylococcus aureus UDP-N-acetylenolpyruvylglucosamine reductase (MurB)., Benson TE, Harris MS, Choi GH, Cialdella JI, Herberg JT, Martin JP Jr, Baldwin ET, Biochemistry. 2001 Feb 27;40(8):2340-50. PMID:11327854
Page seeded by OCA on Tue Nov 20 16:47:55 2007
Categories: Single protein | Staphylococcus aureus | UDP-N-acetylmuramate dehydrogenase | Baldwin, E.T. | Benson, T.E. | Choi, G.H. | Cialdella, J.I. | Harris, M.S. | Herberg, J.T. | Jr., J.P.Martin. | FAD | Cell division | Cell wall | Fad | Flavoprotein | Nadp | Oxidoreductase | Peptidoglycan synthesis
