1htm

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Image:1htm.gif

1htm, resolution 2.5Å

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STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION

Overview

Low pH induces a conformational change in the influenza virus, haemagglutinin, which then mediates fusion of the viral and host cell, membranes. The three-dimensional structure of a fragment of the, haemagglutinin in this conformation reveals a major refolding of the, secondary and tertiary structure of the molecule. The apolar fusion, peptide moves at least 100 A to one tip of the molecule. At the other end, a helical segment unfolds, a subdomain relocates reversing the chain, direction, and part of the structure becomes disordered.

About this Structure

1HTM is a Protein complex structure of sequences from Uncultured beta proteobacterium umtra-608. The following page contains interesting information on the relation of 1HTM with [Hemagglutinin]. Full crystallographic information is available from OCA.

Reference

Structure of influenza haemagglutinin at the pH of membrane fusion., Bullough PA, Hughson FM, Skehel JJ, Wiley DC, Nature. 1994 Sep 1;371(6492):37-43. PMID:8072525

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