1i30

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Image:1i30.gif

1i30, resolution 2.4Å

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E. COLI ENOYL REDUCTASE +NAD+SB385826

Overview

1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and, Escherichia coli enoyl acyl carrier protein reductase (FabI) have been, identified. Crystal structure data shows the inhibitor 1 bound in the, enzyme active site of E. coli FabI.

About this Structure

1I30 is a Single protein structure of sequence from Escherichia coli with NAD and 826 as ligands. Active as [acyl-carrier-protein_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number 1.3.1.9 Full crystallographic information is available from OCA.

Reference

1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)., Heerding DA, Chan G, DeWolf WE, Fosberry AP, Janson CA, Jaworski DD, McManus E, Miller WH, Moore TD, Payne DJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Smith W, Takata DT, Vaidya KS, Yuan CC, Huffman WF, Bioorg Med Chem Lett. 2001 Aug 20;11(16):2061-5. PMID:11514139 [[Category: Enoyl-[acyl-carrier-protein] reductase (NADH)]]

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