1iar
From Proteopedia
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INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX
Contents |
Overview
Interleukin-4 (IL-4) is a principal regulatory cytokine during an immune, response and a crucial determinant for allergy and asthma. IL-4 binds with, high affinity and specificity to the ectodomain of the IL-4 receptor alpha, chain (IL4-BP). Subsequently, this intermediate complex recruits the, common gamma chain (gamma c), thereby initiating transmembrane signaling., The crystal structure of the intermediate complex between human IL-4 and, IL4-BP was determined at 2.3 A resolution. It reveals a novel spatial, orientation of the two proteins, a small but unexpected conformational, change in the receptor-bound IL-4, and an interface with three separate, clusters of trans-interacting residues. Novel insights on ligand binding, in the cytokine receptor family and a paradigm for receptors of IL-2, IL-7, IL-9, and IL-15, which all utilize gamma c, are provided.
Disease
Known diseases associated with this structure: AIDS, slow progression to OMIM:[147781], Atopy, susceptibility to OMIM:[147781]
About this Structure
1IAR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface., Hage T, Sebald W, Reinemer P, Cell. 1999 Apr 16;97(2):271-81. PMID:10219247
Page seeded by OCA on Fri Feb 15 16:00:33 2008
