1ibr

From Proteopedia

proteopedia linkproteopedia link

spinqualitylabelsall models 1ibr, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

COMPLEX OF RAN WITH IMPORTIN BETA

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Transport receptors of the Importin beta family shuttle between the, nucleus and cytoplasm and mediate transport of macromolecules through, nuclear pore complexes. They interact specifically with the GTP-binding, protein Ran, which in turn regulates their interaction with cargo. Here, we report the three-dimensional structure of a complex between Ran bound, to the nonhydrolyzable GTP analog GppNHp and a 462-residue fragment from, Importin beta. The structure of Importin beta shows 10 tandem repeats, resembling HEAT and Armadillo motifs. They form an irregular crescent, the, concave site of which forms the interface with Ran-triphosphate. The, importin-binding site of Ran does not overlap with that of the Ran-binding, domain of RanBP2.

Disease

Known diseases associated with this structure: Osteolysis, familial expansile OMIM:[603499], Paget disease of bone OMIM:[603499]

About this Structure

1IBR is a Protein complex structure of sequences from Homo sapiens with MG and GNP as ligands. Full crystallographic information is available from OCA.

Reference

Structural view of the Ran-Importin beta interaction at 2.3 A resolution., Vetter IR, Arndt A, Kutay U, Gorlich D, Wittinghofer A, Cell. 1999 May 28;97(5):635-46. PMID:10367892

Page seeded by OCA on Mon Nov 12 17:28:32 2007