1w73
From Proteopedia
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BINARY STRUCTURE OF HUMAN DECR SOLVED BY SEMET SAD.
Overview
Fatty acid catabolism by beta-oxidation mainly occurs in mitochondria and, to a lesser degree in peroxisomes. Poly-unsaturated fatty acids are, problematic for beta-oxidation, because the enzymes directly involved are, unable to process all the different double bond conformations and, combinations that occur naturally. In mammals, three accessory proteins, circumvent this problem by catalyzing specific isomerization and reduction, reactions. Central to this process is the NADPH-dependent 2,4-dienoyl-CoA, reductase. We present high resolution crystal structures of human, mitochondrial 2,4-dienoyl-CoA reductase in binary complex with cofactor, and the ternary complex with NADP(+) and substrate, trans-2,trans-4-dienoyl-CoA at 2.1 and 1.75 A resolution, respectively., The enzyme, a ... [(full description)]
About this Structure
1W73 is a [Single protein] structure of sequence from [Homo sapiens] with NAP and GOL as [ligands]. Active as [[1]], with EC number [1.3.1.34]. Full crystallographic information is available from [OCA].
Reference
Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site., Alphey MS, Yu W, Byres E, Li D, Hunter WN, J Biol Chem. 2005 Jan 28;280(4):3068-77. Epub 2004 Nov 6. PMID:15531764
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