1imv
From Proteopedia
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2.85 A crystal structure of PEDF
Overview
Pigment epithelium-derived factor (PEDF), a noninhibitory member of the, serpin superfamily, is the most potent inhibitor of angiogenesis in the, mammalian ocular compartment. It also has neurotrophic activity, both in, the retina and in the central nervous system, and is highly up-regulated, in young versus senescent fibroblasts. To provide a structural basis for, understanding its many biological roles, we have solved the crystal, structure of glycosylated human PEDF to 2.85 A. The structure revealed the, organization of possible receptor and heparin-binding sites, and showed, that, unlike any other previously characterized serpin, PEDF has a, striking asymmetric charge distribution that might be of functional, importance. These results provide a starting point for future detailed, structure/function analyses into possible mechanisms of PEDF action that, could lead to development of therapeutics against uncontrolled, angiogenesis.
About this Structure
1IMV is a Single protein structure of sequence from Homo sapiens with NAG as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor., Simonovic M, Gettins PG, Volz K, Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11131-5. Epub 2001 Sep 18. PMID:11562499
Page seeded by OCA on Mon Nov 12 17:31:58 2007
Categories: Homo sapiens | Single protein | Gettins, P.G.W. | Simonovic, M. | Volz, K. | NAG | Angiogenesis | Pedf | Serpin
