1iqp
From Proteopedia
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Crystal Structure of the Clamp Loader Small Subunit from Pyrococcus furiosus
Overview
In eukaryotic DNA replication, replication factor-C (RFC) acts as the, clamp loader, which correctly installs the sliding clamp onto DNA strands, at replication forks. The eukaryotic RFC is a complex consisting of one, large and four small subunits. We have determined the crystal structure of, the clamp loader small subunit (RFCS) from Pyrococcus furiosus. The six, subunits, of which four bind ADP in their canonical nucleotide binding, clefts, assemble into a dimer of semicircular trimers. The crescent-like, architecture of each subunit formed by the three domains resembles that of, the delta' subunit of the E. coli clamp loader. The trimeric architecture, of archaeal RFCS, with its mobile N-terminal domains, involves, intersubunit interactions that may be conserved in eukaryotic functional, complexes.
About this Structure
1IQP is a Single protein structure of sequence from Pyrococcus furiosus with ADP as ligand. Full crystallographic information is available from OCA.
Reference
Atomic structure of the clamp loader small subunit from Pyrococcus furiosus., Oyama T, Ishino Y, Cann IK, Ishino S, Morikawa K, Mol Cell. 2001 Aug;8(2):455-63. PMID:11545747
Page seeded by OCA on Tue Nov 20 17:35:04 2007
