This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1isn
From Proteopedia
|
Crystal structure of merlin FERM domain
Overview
Neurofibromatosis type 2 (NF2) is a dominantly inherited disease, associated with the central nervous system. The NF2 gene product merlin is, a tumor suppressor, and its mutation or inactivation causes this disease., We report here the crystal structure of the merlin FERM domain containing, a 22-residue alpha-helical segment. The structure reveals that the merlin, FERM domain consists of three subdomains displaying notable features of, the electrostatic surface potentials, although the overall surface, potentials similar to those of ezrin/radixin/moesin (ERM) proteins, indicate electrostatic membrane association. The structure also is, consistent with inactivation mechanisms caused by the pathogenic mutations, associated with NF2.
About this Structure
1ISN is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain., Shimizu T, Seto A, Maita N, Hamada K, Tsukita S, Tsukita S, Hakoshima T, J Biol Chem. 2002 Mar 22;277(12):10332-6. Epub 2001 Dec 27. PMID:11756419
Page seeded by OCA on Tue Nov 20 17:38:22 2007
