4foc

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Image:4foc.jpg

Template:STRUCTURE 4foc

Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 2

Template:ABSTRACT PUBMED 22734674

About this Structure

4foc is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Lewis RT, Bode CM, Choquette D, Potashman M, Romero K, Stellwagen JC, Teffera Y, Moore E, Whittington DA, Chen H, Epstein LF, Emkey R, Andrews PS, Yu V, Saffran DC, Xu M, Drew AE, Merkel P, Szilvassy S, Brake RL. The discovery and optimization of a novel class of potent, selective and orally bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with potential utility for the treatment of cancer. J Med Chem. 2012 Jun 26. PMID:22734674 doi:10.1021/jm3005866

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