1ixz
From Proteopedia
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Crystal structure of the FtsH ATPase domain from Thermus thermophilus
Overview
FtsH is a cytoplasmic membrane-integrated, ATP-dependent metalloprotease, which processively degrades both cytoplasmic and membrane proteins in, concert with unfolding. The FtsH protein is divided into the N-terminal, transmembrane region and the larger C-terminal cytoplasmic region, which, consists of an ATPase domain and a protease domain. We have determined the, crystal structures of the Thermus thermophilus FtsH ATPase domain in the, nucleotide-free and AMP-PNP- and ADP-bound states, in addition to the, domain with the extra preceding segment. Combined with the mapping of the, putative substrate binding region, these structures suggest that FtsH, internally forms a hexameric ring structure, in which ATP binding could, cause a conformational change to facilitate transport of substrates into, the protease domain through the central pore.
About this Structure
1IXZ is a Single protein structure of sequence from Thermus thermophilus with HG and SO4 as ligands. Full crystallographic information is available from OCA.
Reference
Hexameric ring structure of the ATPase domain of the membrane-integrated metalloprotease FtsH from Thermus thermophilus HB8., Niwa H, Tsuchiya D, Makyio H, Yoshida M, Morikawa K, Structure. 2002 Oct;10(10):1415-23. PMID:12377127
Page seeded by OCA on Sat Nov 24 22:45:08 2007
