1jgg

From Proteopedia

Revision as of 16:06, 20 November 2007 by OCA (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
Image:1jgg.gif

1jgg, resolution 2.Å

Drag the structure with the mouse to rotate

Even-skipped Homeodomain Complexed to AT-rich DNA

Overview

even-skipped is a homeobox gene important in controlling segment, patterning in the embryonic fruit fly. Its homeobox encodes a DNA binding, domain which binds with similar affinities to two DNA consensus sequences, one AT-rich, the other GC-rich. We describe a crystallographic analysis of, the Even-skipped homeodomain complexed to an AT-rich oligonucleotide at, 2.0 A resolution. The structure reveals a novel arrangement of two, homeodomains bound to one 10 bp DNA sequence in a tandem fashion. This, arrangement suggests a mechanism for the homeoproteins' regulatory, specificity. In addition, the functionally important residue Gln50 is, observed in multiple conformations making direct and water-mediated, hydrogen bonds with the DNA bases.

About this Structure

1JGG is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structure of the even-skipped homeodomain complexed to AT-rich DNA: new perspectives on homeodomain specificity., Hirsch JA, Aggarwal AK, EMBO J. 1995 Dec 15;14(24):6280-91. PMID:8557047

Page seeded by OCA on Tue Nov 20 18:13:29 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jgg"
Personal tools