1jk8
From Proteopedia
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Crystal structure of a human insulin peptide-HLA-DQ8 complex
Contents |
Overview
The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8, and HLA-DQ2 in humans and I-A(g7) in nonobese diabetic (NOD) mice are the, major risk factors for increased susceptibility to type 1 diabetes. Using, X-ray crystallography, we have determined the three-dimensional structure, of DQ8 complexed with an immunodominant peptide from insulin. The, similarity of the DQ8, DQ2 and I-A(g7) peptide-binding pockets suggests, that diabetes is caused by the same antigen-presentation event(s) in, humans and NOD mice. Correlating type 1 diabetes epidemiology and MHC, sequences with the DQ8 structure suggests that other structural features, of the P9 pocket in addition to position 57 contribute to susceptibility, to type 1 diabetes.
Disease
Known diseases associated with this structure: Celiac disease, susceptibility to OMIM:[146880], Diabetes mellitus, rare form OMIM:[176730], Hyperproinsulinemia, familial OMIM:[176730], MODY, one form OMIM:[176730]
About this Structure
1JK8 is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes., Lee KH, Wucherpfennig KW, Wiley DC, Nat Immunol. 2001 Jun;2(6):501-7. PMID:11376336
Page seeded by OCA on Fri Feb 15 16:07:48 2008
