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ifn-YNS is an interferon alpha 2 mutant with improved affinity to interferon alpha receptor 1 (IFNAR1). it contains three mutations on the interface of the binding site: .[1]
While residue 57 is shown only in ifn beta, which binds IFNAR1 in high affinities, the other two residues does not seem to have any pattern that can suggest that it creates strong binding.
Using aquaprot we predict that the three residues mentioned (YNS) bind to the residues
