Sandbox pia

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Structural model of yeast 26S

About this Structure

4b4t is a 31 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA and described in Beck et al.[1]. The structure is a comparative model which was fitted into an cryo-EM density at 7.4Å resolution. Previous publications describing the architecture are [2] [3] [4]

Structural model of yeast 26S (PDB entry 4b4t)

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Cryo-EM density emdb-2165 used for flexible fitting with MDFF[6] [7] Image:26S.gif

  1. ↑ Beck F, Unverdorben P, Bohn S, Schweitzer A, Pfeifer G, Sakata E, Nickell S, Plitzko JM, Villa E, Baumeister W, Forster F. Near-atomic resolution structural model of the yeast 26S proteasome. Proc Natl Acad Sci U S A. 2012 Aug 27. PMID:22927375 doi:10.1073/pnas.1213333109
  2. ↑ Lasker K, Forster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W. Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1380-7. Epub 2012 Jan 23. PMID:22307589 doi:10.1073/pnas.1120559109
  3. ↑ Lander GC, Estrin E, Matyskiela ME, Bashore C, Nogales E, Martin A. Complete subunit architecture of the proteasome regulatory particle. Nature. 2012 Jan 11;482(7384):186-91. doi: 10.1038/nature10774. PMID:22237024 doi:10.1038/nature10774
  4. ↑ Forster F, Lasker K, Nickell S, Sali A, Baumeister W. Toward an integrated structural model of the 26S proteasome. Mol Cell Proteomics. 2010 Aug;9(8):1666-77. Epub 2010 May 13. PMID:20467039 doi:10.1074/mcp.R000002-MCP201
  5. ↑ . PMID:216315890657
  6. ↑ Trabuco LG, Villa E, Schreiner E, Harrison CB, Schulten K. Molecular dynamics flexible fitting: a practical guide to combine cryo-electron microscopy and X-ray crystallography. Methods. 2009 Oct;49(2):174-80. Epub 2009 May 4. PMID:19398010 doi:10.1016/j.ymeth.2009.04.005
  7. ↑ Beck F, Unverdorben P, Bohn S, Schweitzer A, Pfeifer G, Sakata E, Nickell S, Plitzko JM, Villa E, Baumeister W, Forster F. Near-atomic resolution structural model of the yeast 26S proteasome. Proc Natl Acad Sci U S A. 2012 Aug 27. PMID:22927375 doi:10.1073/pnas.1213333109
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