1jr4

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Image:1jr4.jpg

1jr4, resolution 2.63Å

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CATECHOL O-METHYLTRANSFERASE BISUBSTRATE-INHIBITOR COMPLEX

About this Structure

1JR4 is a Single protein structure of sequence from Rattus norvegicus with MG and CL4 as ligands. Active as Catechol O-methyltransferase, with EC number 2.1.1.6 Full crystallographic information is available from OCA.

Reference

X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity We thank F. Hoffmann-La Roche for generous support of this work. We are grateful to P. Malherbe for the cloning of COMT, P. Caspers for the expression of COMT, A. Cesura for enzyme purification, B. Wipf for fermentation, and H. W. Lahm for sequencing. , Lerner C, Ruf A, Gramlich V, Masjost B, Zurcher G, Jakob-Roetne R, Borroni E, Diederich F, Angew Chem Int Ed Engl. 2001 Nov 5;40(21):4040-4042. PMID:12404486

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