1jy0
From Proteopedia
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Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag and Cys 117 replaced with Val (C117V).
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Overview
An alternative core packing group, involving a set of five positions, has, been introduced into human acidic FGF-1. This alternative group was, designed so as to constrain the primary structure within the core region, to the same threefold symmetry present in the tertiary structure of the, protein fold (the beta-trefoil superfold). The alternative core is, essentially indistinguishable from the WT core with regard to structure, stability, and folding kinetics. The results show that the beta-trefoil, superfold is compatible with a threefold symmetric constraint on the core, region, as might be the case if the superfold arose as a result of gene, duplication/fusion events. Furthermore, this new core arrangement can form, the basis of a structural "building block" that can greatly simplify the, de novo design of beta-trefoil proteins by using symmetric structural, complementarity. Remaining asymmetry within the core appears to be related, to asymmetry in the tertiary structure associated with receptor and, heparin binding functionality of the growth factor.
Disease
Known diseases associated with this structure: Aplasia of lacrimal and salivary glands OMIM:[602115], LADD syndrome OMIM:[602115]
About this Structure
1JY0 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Accommodation of a highly symmetric core within a symmetric protein superfold., Brych SR, Kim J, Logan TM, Blaber M, Protein Sci. 2003 Dec;12(12):2704-18. PMID:14627732
Page seeded by OCA on Fri Feb 15 16:10:14 2008
