1jy5

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Image:1jy5.gif

1jy5, resolution 2.05Å

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RNase-related protein from Calystegia sepium

Overview

The structure of a catalytically inactive RNase-related protein from, Calystegia sepium (CalsepRRP) has been resolved by protein crystallography, at a resolution of 2.05 A and an R factor of 20.74%. Although the protein, is completely devoid of ribonuclease activity, it adopts the typical alpha, + beta structure of non-base-specific RNases. Analysis of the structure, revealed that two amino-acid substitutions in the 'active' P1 site, in, combination with the less hydrophobic/aromatic character of the B1, base-recognition site and a completely disrupted B2 base-recognition site, might account for this complete lack of activity.

About this Structure

1JY5 is a Single protein structure of sequence from Calystegia sepium. Full crystallographic information is available from OCA.

Reference

Structure of an RNase-related protein from Calystegia sepium., Rabijns A, Verboven C, Rouge P, Barre A, Van Damme EJ, Peumans WJ, De Ranter CJ, Acta Crystallogr D Biol Crystallogr. 2002 Apr;58(Pt 4):627-33. Epub 2002, Mar 22. PMID:11914487

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