Fragment-Based Drug Discovery

This represents the inhibition of the anti-apoptotic protein, Bcl-xl, by the anti-cancer drug, paclitaxel.

Shown here is the interaction between paclitaxel and the protein via . The hydrogen bond is formed between an oxygen (red) from the sulfoxone portion of the drug to an "N-H" group (grey) of a glycine amino acid.

Shown here is the formed between the protein (grey) and a hydrophobic portion of paclitaxel (blue).