Fragment-Based Drug Discovery

This represents the binding of the anti-cancer drug, paclitaxel, to the anti-apoptotic protein, Bcl-xl.

Shown here is the interaction between paclitaxel and the protein via . The hydrogen bond is formed between an oxygen from the sulfoxone portion of the drug to an "N-H" group of a glycine amino acid.

Shown here is the formed between the protein and a hydrophobic portion of paclitaxel.