1k83

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Image:1k83.gif

1k83, resolution 2.80Å

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Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin

Overview

The structure of RNA polymerase II in a complex with the inhibitor, alpha-amanitin has been determined by x-ray crystallography. The structure, of the complex indicates the likely basis of inhibition and gives, unexpected insight into the transcription mechanism.

About this Structure

1K83 is a Protein complex structure of sequences from Amanita phalloides and Saccharomyces cerevisiae with ZN and MN as ligands. The following page contains interesting information on the relation of 1K83 with [RNA Polymerase]. Active as DNA-directed RNA polymerase, with EC number 2.7.7.6 Full crystallographic information is available from OCA.

Reference

Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution., Bushnell DA, Cramer P, Kornberg RD, Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1218-22. Epub 2002 Jan 22. PMID:11805306

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