Sfp is a 4'-phosphopantetheinyl transferase endogenous to B. Subtilis, first crystallized in 1999 [1]. The function of Sfp is transfer a phosphopantetheinyl group from coenzyme-A (CoA-SH) (spacefill) to the serine residue of peptides containing the sequence "DSL". Frequently this sequence is found in acyl- or peptidyl-carrier proteins in fatty acid synthases (FASs), polyketide synthases (PKSs), and nonribosomal peptide synthetases (NRPSs). This converts the inactive apo form peptide to the active holo form.
Sfp fr
