Growth factor receptor-bound protein 2 (GRB2) is an adaptor protein. It links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction.
3D structures of Grb2
1ghu – hGRB2 SH2 domain (mutant) – human
1fhs, 1jyu, 2aoa, 2h46 - hGRB2 SH2 domain
2vvk, 2vwf, 2w0z - hGRB2 SH3 domain
1tze, 1bmb, 1bm2, 1zfp, 1qg1, 1jyq, 1jyr, 2aob, 2h5k, 2huw, 3c7i, 3imd, 3imj, 3in7, 3in8, 3kfj, 3n8m, 3n7y, 3n84, 3mxc, 3mxy, 3ov1, 3ove, 3s8n, 3s8o - hGRB2 SH2 domain + phosphotyrosyl peptide
1x0n - hGRB2 SH2 domain + inhibitor
1cj1 - hGRB2 SH2 domain + phosphotyrosyl derivative
1gbq, 2gbq, 3gbq, 4gbq, 1aze - GRB2 SH3 domain + SOS-1 peptide – NMR
1io6, 1h3h - GRB2 SH3 domain + ligand peptide – NMR
