1kwa
From Proteopedia
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HUMAN CASK/LIN-2 PDZ DOMAIN
Overview
PDZ domain containing proteins assist formation of cell-cell junctions and, localization of membrane protein receptors and ion channels. PDZ domains, interact with the C-terminal residues of a particular target membrane, protein. Based on their binding specificities and sequence homologies, PDZ, domains fall into two classes. The first crystal structure of a class II, PDZ domain, that of hCASK, has been solved by multi-wavelength anomalous, dispersion phasing. Complex formation with the C-terminus of a neighboring, non-crystallographically related PDZ domain reveals interactions between, hCASK and its ligand. Class II PDZ domains differ from class I domains by, formation of a second hydrophobic binding pocket. The C-terminal, carboxylate binding loop of the PDZ domain is structurally conserved in, both classes suggesting a generalized carboxylate binding motif (h-Gly-h), where h is a hydrophobic residue.
About this Structure
1KWA is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition., Daniels DL, Cohen AR, Anderson JM, Brunger AT, Nat Struct Biol. 1998 Apr;5(4):317-25. PMID:9546224
Page seeded by OCA on Fri Feb 15 16:15:26 2008
